Comprehensive analysis of constitutional mismatch repair deficiency-associated non-Hodgkin lymphomas in a global cohort.
Charlotte RigaudVictoria J ForsterHiba Al-TarrahAndishe AttarbaschiVanessa BianchiAmos BurkeBirgit BurkhardtChrystelle ColasChristine DevalckMelissa EdwardsSarah ElitzurAnne-Kathrin GartheYael GoldbergLéa Guerrini-RousseauSukanya HorpaopanDanuta Januszkiewicz-LewandowskaEdita KabíčkováChristian P KratzJan LoeffenVanessa Pérez-AlonsoMarta PinedaVeronique Minard ColinDaniel RuedaClara Ruiz-PonteAmelie TrinquandAnne UyttebroeckKatharina WimmerAnne AuperinUri TaboriLaurence BrugieresPublished in: Pediatric blood & cancer (2024)
Standard treatments for sporadic NHL are effective in most CMMRD-associated NHL cases, but multiple malignancies, including lymphomas, impair prognosis. Future strategies should evaluate the potential of less genotoxic therapies, including immunotherapy, in preventing SMLs while maintaining effective control of NHL.