Plasma neurofilament light levels are associated with risk of disability in multiple sclerosis.

Ali ManouchehriniaPernilla StridhMohsen KhademiDavid LeppertChristian BarroZuzanna MichalakPascal BenkertJan LyckeLars AlfredssonLudwig KapposFredrik PiehlTomas OlssonJens KuhleIngrid Kockum

Published in: Neurology (2020)

Elevated pNfL levels at early stages of MS are associated with an increased risk of reaching sustained disability worsening. Hence, pNfL may serve as a prognostic tool to assess the risk of developing permanent disability in MS.

Keyphrases

multiple sclerosis

white matter

mass spectrometry

cerebrospinal fluid