Effects of antibiotics on the anti-tumor efficacy of immune checkpoint inhibitor therapy.
Fangfang NieJunGang GuoJiaYi PanZhaoJiao GuoChun WangJun YanWeina MaPublished in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2024)
ATB use is negatively correlated with ICI therapy efficacy, leading to reduced PFS and OS in patients undergoing such treatment. Owing to the significant impact of ATBs on the human gut microbiome, regulation of the gut microbiome may emerge as a novel therapeutic target that can enhance the clinical activity of ICIs.