The risk of thyroid dysfunction in PD-1 blockade is stratified by the pattern of TgAb and TPOAb positivity at baseline.
Xin ZhouShintaro IwamaTomoko KobayashiMasahiko AndoHiroshi ArimaPublished in: The Journal of clinical endocrinology and metabolism (2023)
The risk of thyroid-irAEs was affected by the pattern of TgAb and TPOAb positivity at baseline; there were high risks of thyrotoxicosis in patients with TgAb-(+) and of hypothyroidism in patients with TgAb-(+) and those with TPOAb-(+).