Heavy Water (D2O) Containing Preservation Solution Reduces Hepatic Cold Preservation and Reperfusion Injury in an Isolated Perfused Rat Liver (IPRL) Model.
Shingo ShimadaMoto FukaiKengo ShibataSodai SakamotoKenji WakayamaTakahisa IshikawaNorio KawamuraMasato FujiyoshiTsuyoshi ShimamuraAkinobu TaketomiPublished in: Journal of clinical medicine (2019)
Dsol reduced hepatic IRI after extended cold preservation and subsequent reperfusion. The protection was primarily due to the maintenance of mitochondrial function, cytoskeletal integrity, leading to limiting oxidative stress, apoptosis, and necrosis pathways.
Keyphrases
- oxidative stress
- cerebral ischemia
- acute myocardial infarction
- acute ischemic stroke
- diabetic rats
- dna damage
- ischemia reperfusion injury
- endoplasmic reticulum stress
- induced apoptosis
- cell cycle arrest
- subarachnoid hemorrhage
- heart failure
- brain injury
- acute coronary syndrome
- signaling pathway
- atrial fibrillation