Comparison of DNA methylation patterns across tissue types in infants with tetralogy of Fallot.

Jennifer S NelsonCheuk KwokNicholas E BragancaDaralys L LopezAndrea P Espina ReyMatthew RobinsonSteven N Ebert

Published in: Birth defects research (2022)

Compared with blood, buccal tissue more closely mirrors the myocardial methylome, with >10-fold similarity. Nevertheless, both buccal and blood tissue capture highly conserved DNA methylation patterns at specific genetic loci related to cardiac development. Buccal cheek swabs may be a useful surrogate tissue type for future investigations of TOF-specific epigenetic profiles.

Keyphrases

dna methylation
genome wide
gene expression
mass spectrometry
ms ms
heart failure
copy number