The GLP-1 analog, liraglutide prevents the increase of proinflammatory mediators in the hippocampus of male rat pups submitted to maternal perinatal food restriction.
Yolanda Diz-ChavesL TobaJ FandiñoL C González-MatíasL M Garcia-SeguraF MalloPublished in: Journal of neuroinflammation (2018)
Therefore, the GLP-1 analog, liraglutide, emerges as neuroprotective drug that minimizes the harmful effects of maternal food restriction, decreasing neuroinflammation in the hippocampus in a very early stage.
Keyphrases
- cerebral ischemia
- early stage
- birth weight
- cognitive impairment
- subarachnoid hemorrhage
- pregnancy outcomes
- brain injury
- blood brain barrier
- human health
- pregnant women
- prefrontal cortex
- oxidative stress
- traumatic brain injury
- lipopolysaccharide induced
- emergency department
- sentinel lymph node
- mouse model
- squamous cell carcinoma
- inflammatory response
- body mass index
- climate change
- adverse drug
- rectal cancer
- electronic health record