Costimulatory domains direct distinct fates of CAR-driven T cell dysfunction.
Mehmet Emrah SelliJack H LandmannMarina TerekhovaJohn LattinAmanda HeardYu-Sung HsuTien-Ching ChangJufang ChangJohn WarringtonHelen HaNatalie KingstonGraham HoggMichael SladeMelissa M Berrien-ElliotMark FosterSamantha Kersting-SchadekAgata GruszczynskaDavid DeNardoTodd A FehnigerMaxim N ArtyomovNathan SinghPublished in: bioRxiv : the preprint server for biology (2023)
Chronic stimulation of CARs containing the 41BB costimulatory domain leads to a novel state of T cell dysfunction that is distinct from T cell exhaustion.