The capsaicin receptor TRPV1 is the first line defense protecting from acute non damaging heat: a translational approach.

Daniela Constanze Rosenberger Uta Binzen Rolf-Detlef Treede Wolfgang Greffrath

Published in: Journal of translational medicine (2020)

TRPV1-expressing nociceptors encode transient non-damaging heat pain in humans, thermal gating of TRPV1 is similar in HEK cells and DRG neurons, and TRPV1 tachyphylaxis is an important modulator of heat pain sensitivity. These findings suggest that TRPV1 expressed in dermal and epidermal populations of nociceptors serves as first line defense against heat injury.

Keyphrases

neuropathic pain
spinal cord
heat stress
chronic pain
spinal cord injury
pain management
induced apoptosis
liver failure
respiratory failure
intensive care unit
hepatitis b virus
innate immune
endoplasmic reticulum stress
wound healing
acute respiratory distress syndrome
mechanical ventilation