PBOV1 as a potential biomarker for more advanced prostate cancer based on protein and digital histomorphometric analysis.

Neil M CarletonGuangjing ZhuMikhail GorbounovM Craig MillerKenneth J PientaLinda M S ResarRobert W Veltri

Published in: The Prostate (2018)

Our study demonstrates that the PBOV1 protein could be used to discriminate Grade Group 3 and above PCa. Additionally, the PBOV1 protein could be involved in modulating changes to the nuclear architecture of PCa cells. Confirmatory studies are warranted in an independent population for further validation.

Keyphrases

prostate cancer
protein protein
amino acid
binding protein
signaling pathway
small molecule
cell cycle arrest
oxidative stress
endoplasmic reticulum stress