Macro-clusters: CD301b+ DCs prime Th2 responses.

Published in: The Journal of experimental medicine (2024)

In this issue of JEM, Lyons-Cohen et al. (https://doi.org/10.1084/jem.20231282) reveal that lymph node macro-clusters provide a spatial niche where CD301b+ cDC2s and CD4+ T cells interact. These integrin-mediated cellular hubs promote enhanced co-stimulation and cytokine signaling to drive Th2 differentiation.

Keyphrases

lymph node
nk cells
genome wide
neoadjuvant chemotherapy
squamous cell carcinoma
single cell
cell cycle
sentinel lymph node
radiation therapy
early stage
cell proliferation
rectal cancer