New benzoquinone pigments from the hydnoid fungus Sarcodontia setosa and their biosynthetic relationship.
Andrei K WhaleyAnastasiia O PonkratovaAnastasia A OrlovaSergey V VolobuevNatalya V ShakhovaVladimir SharoykoSergey N SmirnovNatalia V PustovitLiudmila A KraevaVladimir G LuzhaninPublished in: Natural product research (2023)
Chemical investigation of the hydnoid fungus Sarcodontia setosa resulted in the isolation of five compounds, including two new sarcodontic acid derivatives - setosic acid ( 1 ) and 7,8-dehydrohomosarcodontic acid ( 2 ) along with three known benzoquinone pigments - sarcodontic acid ( 3 ), 4,5-dehydrosarcodontic acid ( 4 ) and dihydrosarcodontic acid ( 5 ). The structures were elucidated using spectroscopic methods (UV, NMR and HR-ESIMS). The biosynthetic relationship of the isolated compounds is proposed and discussed. Antibacterial activity screening of compounds 1 - 5 against ESKAPE bacterial strains in vitro with zones of inhibition was performed and MIC values were established for the most active compounds ( 3 and 5 ).