The Novel Pyridazine Pyrazolecarboxamide Insecticide Dimpropyridaz Inhibits Chordotonal Organ Function Upstream of Trpv Channels.

PPCs are a new class of chordotonal organ modulator insecticides for control of piercing-sucking pests. Dimpropyridaz is a PPC proinsecticide that is activated in target insects to secondary amide forms that inhibit the firing of chordotonal organs. The inhibition occurs at a site upstream of TRPVs and is TRPV-independent, providing a novel mode of action for resistance management. This article is protected by copyright. All rights reserved.