Pre-conditioning of gingival epithelial cells with sub-apoptotic concentrations of curcumin prevents pro-inflammatory cytokine release.

Melissa M GrantAnn E ScottJohn B MatthewsHelen R GriffithsIain L C Chapple

Published in: Journal of periodontal research (2023)

Curcumin decreased inflammatory cytokine production induced by Fusobacterium nucleatum in H400 oral epithelial cells. The mechanism of action appears to be driven by the increase of haem oxygenase and the production of carbon monoxide.

Keyphrases

cell death
oxidative stress
mouse model
anti inflammatory