Targeting the tyrosine kinase Src in endothelium attenuates inflammation and atherogenesis induced by disturbed flow.

Huanyu Ding Minchun Jiang Andrew Man Lok Chan Yin Xia Ronald Ching-Wan Ma Xiaoqiang Yao Li Wang Yu Huang

Published in: British journal of pharmacology (2024)

Disturbed flow promotes endothelial inflammation and atherogenesis through the Piezo1-Src-Stat3 pathway. Therefore, inhibiting Src in endothelial cells could be a promising therapeutic strategy to treat atherogenesis.

Keyphrases

tyrosine kinase
endothelial cells
epidermal growth factor receptor
oxidative stress
nitric oxide
signaling pathway
cell proliferation
high glucose
cancer therapy
drug delivery