Lactobacillus casei Cell Wall Extract and Production of Galactose-Deficient IgA1 in a Humanized IGHA1 Mouse Model.

Run LiManliu WangJingyi Li Li Zhu Xinfang XieHui WangXu ZhangWenmin TianYong Zhang Yaping DongJincan ZanHongyu LiYue-Miao Zhang Xu-Jie Zhou Su-Fang ShiChutian ShuLi-Jun LiuJing JinJicheng LvHong Zhang

Published in: Journal of the American Society of Nephrology : JASN (2024)

We observed elevated plasma Gd-IgA1 levels with kidney deposition of IgA1 in the IGHA1+/+ mice following LCWE and CFA. In conjunction with factor H mutation, the mice exhibited severe glomerular alterations, associated with hematuria and albuminuria in resemblance of clinical IgA nephropathy.

Keyphrases

cell wall
mouse model
high fat diet induced
oxidative stress
early onset
type diabetes
monoclonal antibody