Meprin-α (Mep1A) enhances TNF-α secretion by mast cells and aggravates abdominal aortic aneurysms.

Ran GaoDuan LiuWenjun GuoWeipeng GeTianfei FanBolun LiPan GaoBin LiuYuehong ZhengJiangning Liu

Published in: British journal of pharmacology (2020)

Taken together, these data suggest that Mep1A may be vital in AAA pathophysiology by regulating TNF-α production by MCs. Knocking out Mep1A significantly decreased AAA diameter and improved AAA stability in mice. Therefore, Mep1A is a potential new therapeutic target in the development of AAA.

Keyphrases

abdominal aortic
rheumatoid arthritis
electronic health record
big data
risk assessment
high fat diet induced
artificial intelligence
optic nerve
data analysis
wild type