Systemic and central nervous system neuroinflammatory signatures of neuropsychiatric symptoms and related cognitive decline in older people.
Christopher ClarkJonas RichiardiBénédicte MaréchalGene L BowmanLoïc DayonJulius PoppPublished in: Journal of neuroinflammation (2022)
Distinct systemic and CNS inflammatory processes are involved in the pathophysiology of NPS in older people. Neuroinflammation may explain the link between NPS and more rapid clinical disease progression.
Keyphrases
- cognitive decline
- mild cognitive impairment
- lipopolysaccharide induced
- blood brain barrier
- oxide nanoparticles
- lps induced
- genome wide
- cognitive impairment
- cerebrospinal fluid
- cerebral ischemia
- sleep quality
- dna methylation
- physical activity
- loop mediated isothermal amplification
- gene expression
- depressive symptoms
- subarachnoid hemorrhage