Lower S-adenosylmethionine levels and DNA hypomethylation of placental growth factor (PlGF) in placental tissue of early-onset preeclampsia-complicated pregnancies.
Sandra G HeilEmilie M HerzogPieter H GriffioenBertrand van ZelstSten P WillemsenYolanda B de RijkeRegine P M Steegers-TheunissenEric A P SteegersPublished in: PloS one (2019)
The hypomethylation state of the placenta in EOPE, which is reflected by lower SAM and PlGF DNA hypomethylation underlines the possible role of placental DNA hypomethylation in the pathophysiology of EOPE, which needs further investigation.