Preclinical Development of CAR T Cells with Antigen-Inducible IL18 Enforcement to Treat GD2-Positive Solid Cancers.

Lena Fischer-Riepe Sareetha Kailayangiri Katharina Zimmermann Rita Pfeifer Michael Aigner Bianca Altvater Sascha Kretschmann Simon Völkl Jordan Hartley Celine Dreger Katja Petry Andreas Bosio Angelika von Döllen Wolfgang Hartmann Holger N Lode Dennis Görlich Andreas Mackensen Melanie Jungblut Axel Schambach Hinrich Abken Claudia Rossig

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

These results pave the way for clinical investigation of GD2IL18CART in pediatric and adult patients with neuroblastoma and other GD2-positive cancers (EU CT 2022-501725-21-00).

Keyphrases

induced apoptosis
cell cycle arrest
computed tomography
image quality
stem cells
cell therapy
positron emission tomography
cell death
childhood cancer
bone marrow
pet ct