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Sevoflurane causes cognitive impairment by inducing iron deficiency and inhibiting the proliferation of neural precursor cells in infant mice.

Yong ZuoJinhong XieXue ZhangAnand ThirupathiXiaopeng LiuDi ZhangJianhua ZhangZhenhua Shi
Published in: CNS neuroscience & therapeutics (2024)
The results from the present study demonstrated that Sev-induced iron deficiency might be a new mechanism of cognitive impairment caused by inhaled anesthetics in infant mice. Iron supplementation before anesthesia is an effective strategy to prevent cognitive impairment caused by Sev in infants.
Keyphrases
  • iron deficiency
  • cognitive impairment
  • signaling pathway
  • induced apoptosis
  • high fat diet induced
  • cystic fibrosis
  • type diabetes
  • metabolic syndrome
  • wild type
  • cell death
  • drug induced
  • cell proliferation
  • pi k akt