Critical role of OX40 in drug-induced acute liver injury.

Chunpan ZhangHua JinYan WangChangying LiXinyan ZhaoYanmeng LiWen ShiYue TianHufeng XuDan TianKai LiuJidong JiaGuangyong SunDong Zhang

Published in: British journal of pharmacology (2020)

OX40 is a key molecule that promotes both pro-inflammatory macrophage and CD4+ T-cell function, exacerbating paracetamol-induced liver injury. OX40 could serve as a diagnostic index and therapeutic target of DILI.

Keyphrases

drug induced
liver injury
low density lipoprotein
adverse drug
adipose tissue