Renal complications of lipodystrophy: A closer look at the natural history of kidney disease.

Barış AkıncıSadiye Mehtat UnluAli CelikIlgin Yildirim SimsirSait SenBanu NurFatma Ela KeskinBasak Ozgen SaydamNilufer Kutbay OzdemirBanu Sarer YurekliBekir Ugur ErgurMelda SonmezTahir AtikAtakan ArslanTevfik DemirCanan AltayUlku Aybuke TuncTugba ArkanRamazan GenErdal ErenGulcin AkinciAslihan Arasli YilmazHabib BilenSamim OzenAygul CeltikSenay Savas ErdeveSemra CetinkayaHuseyin OnaySulen SariogluElif Arioglu Oral

Published in: Clinical endocrinology (2018)

CKD is conspicuously frequent in patients with lipodystrophy which has an early onset. Renal involvement appears multifactorial. While poorly controlled diabetes caused by severe insulin resistance may drive the disease in some cases, inherent underlying genetic defects may also lead to cell autonomous mechanisms contributory to the pathogenesis of kidney disease.

Keyphrases

early onset
late onset
insulin resistance
type diabetes
glycemic control
cardiovascular disease
single cell
chronic kidney disease
adipose tissue
metabolic syndrome
risk factors
high fat diet
stem cells
polycystic ovary syndrome
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