GV-971 attenuates the progression of neuromyelitis optica in murine models and reverses alterations in gut microbiota and associated peripheral abnormalities.

Xinying YangZhongheng ZhangyiAisong YuQinming ZhouAihua XiaJi QiuMeixiang CaiXingkun ChuLiang LiZhengnan FengZhiyu LuoGuangqiang SunJing ZhangMeiyu GengSheng ChenZuoquan Xie

Published in: CNS neuroscience & therapeutics (2024)

GV-971 attenuates the progression of NMOSD in murine models and reduces neuroinflammation and injury, likely through its effects on remodeling gut microbiota and peripheral inflammation and metabolic disorders.

Keyphrases

oxidative stress
chemotherapy induced
traumatic brain injury
lps induced
inflammatory response