Critical Illness Risk and Long-Term Outcomes Following Intensive Care in Pediatric Hematopoietic Cell Transplant Recipients.
Matthew S ZinterRuta BrazauskasJoelle StromStella ChenStephanie Bo-SubaitAkshay SharmaAmer BeitinjanehDimana DimitrovaGreg GuilcherJaime PreusslerKasiani MyersNeel S BhattOlle RingdenPeiman HemattiRobert J HayashiSagar PatelSatiro Nakamura De OliveiraSeth RotzSherif M BadawyTaiga NishihoriDavid BuchbinderBetty HamiltonBipin P SavaniHélène SchoemansMohamed SorrorLena WinestoneChristine DuncanRachel PhelanChristopher C DvorakPublished in: medRxiv : the preprint server for health sciences (2023)
Intensive care management is common in pediatric HCT patients. Survival to ICU discharge is high, but ongoing complications necessitate recurrent ICU admission and lead to a poor 1-year outcome in many patients. Together, these data suggest an ongoing burden of toxicity in pediatric HCT patients that continues to limit long-term survival.
Keyphrases
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- intensive care unit
- peritoneal dialysis
- emergency department
- prognostic factors
- oxidative stress
- patient reported outcomes
- risk factors
- mesenchymal stem cells
- signaling pathway
- cell therapy
- mechanical ventilation
- acute respiratory distress syndrome
- pi k akt
- free survival