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IDHwt and IDHmut adult-type diffuse gliomas display distinct alterations in ribosome biogenesis and 2'O-methylation of ribosomal RNA.

Hermes ParaqindesNour-El-Houda MourksiSamantha BallestaJordan HedjamFleur BourdelaisTanguy FenouilThiebaud PicartFrédéric CatezThéo CombeAnthony FerrariJanice KielbassaEmilie ThomasLaurie TononAlain ViariValéry AttignonMarjorie CarrereJessie PerrossierStéphane GiraudChristophe VanbelleMathieu GabutDanny BergeronMichelle S ScottLuis Castro VegaNathalie MagneEmmanuelle HuillardMarc SansonDavid MeyronetJean-Jacques DiazFrançois DucrayVirginie MarcelSébastien Durand
Published in: Neuro-oncology (2023)
In HGGs, IDH mutational status is associated with specific alterations of the ribosome biology and with distinct sensitivities to RNA Pol I inhibitors.
Keyphrases
  • low grade
  • high grade
  • nucleic acid
  • dna methylation
  • genome wide
  • gene expression