IDHwt and IDHmut adult-type diffuse gliomas display distinct alterations in ribosome biogenesis and 2'O-methylation of ribosomal RNA.
Hermes ParaqindesNour-El-Houda MourksiSamantha BallestaJordan HedjamFleur BourdelaisTanguy FenouilThiebaud PicartFrédéric CatezThéo CombeAnthony FerrariJanice KielbassaEmilie ThomasLaurie TononAlain ViariValéry AttignonMarjorie CarrereJessie PerrossierStéphane GiraudChristophe VanbelleMathieu GabutDanny BergeronMichelle S ScottLuis Castro VegaNathalie MagneEmmanuelle HuillardMarc SansonDavid MeyronetJean-Jacques DiazFrançois DucrayVirginie MarcelSébastien DurandPublished in: Neuro-oncology (2023)
In HGGs, IDH mutational status is associated with specific alterations of the ribosome biology and with distinct sensitivities to RNA Pol I inhibitors.