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Therapy-related Myeloid Neoplasms Following PARP Inhibitors: Real-life Experience.

Vincent MarmousetJustine DecroocqSylvain GarciazGabriel EtienneAmine BelhabriSarah BertoliLauris GastaudCélestine SimandSylvain P ChantepieMadalina UzunovAlexis GenthonCeline BerthonEdmond ChichePierre-Yves DumasJacques VargaftigGéraldine SalmeronEmilie LemasleEmmanuelle TavernierJérémy DelageMarion LoiratNadine MorineauFélix Blanc-DurandPatricia PautierVéronique VergéNathalie AugerMyrtille ThomasLaetitia StefaniMarion LepelleyThomas BoyerSylvain ThépotMarie-Pierre GourinPascal BourquardMatthieu DuchmannPierre-Marie MoriceMauricette MichalletLionel AdesPierre FenauxChristian RecherHervé DombretArnaud PagèsChristophe MarzacAlexandra LearyJean-Baptiste Micolnull null
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
In a large series, we described a high incidence of t-MN post-PARPi associated with unfavorable cytogenetic and molecular abnormalities leading to poor OS. Early detection is crucial, particularly in cases of delayed cytopenia.
Keyphrases
  • dna damage
  • risk factors
  • bone marrow
  • dendritic cells
  • dna repair
  • acute myeloid leukemia
  • room temperature
  • mesenchymal stem cells
  • transition metal
  • replacement therapy