Microparticles in systemic sclerosis: Potential pro-inflammatory mediators and pulmonary hypertension biomarkers.
Matthew R LammiLesley Ann SaketkooSamuel C OkpechiMohamed A GhonimDorota WyczechowskaNatalie BauerKusma PyakurelSaito SaitoBennett P deBoisblancA Hamid BoularesPublished in: Respirology (Carlton, Vic.) (2019)
EMP (particularly CD144+) are promising biomarkers of PAH in SSc but require further study. MP isolated from SSc patients induced an increase in endothelial cell inflammation and may be an important pathogenic factor in SSc.
Keyphrases
- systemic sclerosis
- pulmonary hypertension
- interstitial lung disease
- end stage renal disease
- high glucose
- newly diagnosed
- ejection fraction
- oxidative stress
- endothelial cells
- chronic kidney disease
- prognostic factors
- diabetic rats
- patient reported outcomes
- pulmonary arterial hypertension
- pulmonary artery
- risk assessment
- polycyclic aromatic hydrocarbons