Identifying the Carcinogenic Mechanism of Malignant Struma Ovarii Using Whole-Exome Sequencing and DNA Methylation Analysis.

Hitomi YamashitaKentaro NakayamaKosuke KannoTomoka IshibashiMasako IshikawaSeiya SatoKoji IidaSultana RaziaSatoru Kyo

Published in: Current issues in molecular biology (2023)

Somatic UPD and DNA methylation in tumor suppressor genes may be associated with the pathogenesis of malignant struma ovarii. To our knowledge, this is the first report of whole-exome sequencing and DNA methylation analysis in malignant struma ovarii. Genetic and DNA methylation analysis may help elucidate the mechanism of carcinogenesis in rare diseases and guide treatment decisions.

Keyphrases

dna methylation
genome wide
gene expression
copy number
healthcare
transcription factor
polycyclic aromatic hydrocarbons