Association of Sputum Neutrophil Extracellular Trap Subsets With IgA Anti-Citrullinated Protein Antibodies in Subjects at Risk for Rheumatoid Arthritis.
Yuko OkamotoStephanie DevoeNickie SetoValerie MinarchickTimothy M WilsonHeather M RothfussMichael P MohningJaron ArbetMiranda KroehlAshley VisserJustin AugustStacey M ThomasLaura Lenis CharryChelsie FleischerMarie L FeserAshley A Frazer-AbelJill M NorrisBrian D CherringtonWilliam J JanssenMariana J KaplanKevin D DeaneV Michael HolersM Kristen DemoruellePublished in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
These data support a potential mechanism for mucosal ACPA generation in subjects at risk of developing RA, whereby inflammation leads to increased citrullinated protein-expressing NETs that promote local ACPA generation.
Keyphrases
- rheumatoid arthritis
- disease activity
- protein protein
- oxidative stress
- cystic fibrosis
- amino acid
- mycobacterium tuberculosis
- binding protein
- small molecule
- interstitial lung disease
- electronic health record
- pulmonary tuberculosis
- systemic lupus erythematosus
- risk assessment
- human health
- systemic sclerosis
- data analysis