Acyclovir Brain Disposition: Interactions with P-gp, Bcrp, Mrp2, and Oat3 at the Blood-Brain Barrier.
Yuheng ShanYuying CenYanjin ZhangRuishu TanJiahua ZhaoZhiyong NieJiatang ZhangShengyuan YuPublished in: European journal of drug metabolism and pharmacokinetics (2022)
The present study demonstrated that P-gp, Bcrp, Mrp2, and Oat3 inhibition increased the penetration of acyclovir across the BBB, supporting the hypothesis that these efflux pumps restrict the distribution of acyclovir in the brain.