Vitamin D Attenuates Fibrotic Properties of Fibrous Dysplasia-Derived Cells for the Transit towards Osteocytic Phenotype.
Ha-Young KimJung-Hee ShimBaek-Kyu KimChan Young HeoPublished in: International journal of molecular sciences (2024)
Fibrous dysplasia (FD) poses a therapeutic challenge due to the dysregulated extracellular matrix (ECM) accumulation within affected bone tissues. In this study, we investigate the therapeutic potential of 1,25-dihydroxyvitamin D3 (1,25(OH) 2 D 3 ) in managing FD by examining its effects on FD-derived cells in vitro. Our findings demonstrate that 1,25(OH) 2 D 3 treatment attenuates the pro-fibrotic phenotype of FD-derived cells by suppressing the expression of key pro-fibrotic markers and inhibiting cell proliferation and migration. Moreover, 1,25(OH) 2 D 3 enhances mineralization by attenuating pre-osteoblastic cellular hyperactivity and promoting maturation towards an osteocytic phenotype. These results offer valuable insights into potential treatments for FD, highlighting the role of 1,25(OH) 2 D 3 in modulating the pathological properties of FD-derived cells.
Keyphrases
- induced apoptosis
- cell cycle arrest
- extracellular matrix
- signaling pathway
- endoplasmic reticulum stress
- oxidative stress
- idiopathic pulmonary fibrosis
- gene expression
- systemic sclerosis
- cell death
- risk assessment
- cell proliferation
- single cell
- bone mineral density
- climate change
- soft tissue
- replacement therapy
- human health
- smoking cessation