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Residual pyruvate kinase activity in PKLR-deficient erythroid precursors of a patient suffering from severe haemolytic anaemia.

Thomas R L KleiSima Kheradmand KiaMartijn VeldthuisBoukje M BeugerJudy GeisslerJavad DehbozorgianMehran KarimiRobin van BruggenRob van Zwieten
Published in: European journal of haematology (2017)
We conclude that PKM2 rescues glycolysis in PK-R-deficient erythroid precursors.
Keyphrases
  • case report
  • early onset
  • mouse model
  • protein kinase
  • tyrosine kinase
  • drug induced