Intratumoral heterogeneity of MYC drives medulloblastoma metastasis and angiogenesis.
Nan QinEunice PaisanaMaike LanginiDaniel PicardBastian MalzkornCarlos CustódiaRita CascãoFrauke-Dorothee MeyerLena BlümelSarah GöbbelsKübra TabanJasmin BartlNicole BechmannCatleen ConradJan GravemeyerJürgen C BeckerAnja StefanskiStéphanie PugetJoão T BarataKai StühlerUte FischerJörg FelsbergOlivier AyraultGuido ReifenbergerArndt BorkhardtGraeme EisenhoferClaudia C FariaMarc RemkePublished in: Neuro-oncology (2022)
Our study reveals the functional relevance of clonal diversity and highlights the therapeutic potential of targeting the secretome to interrupt interclonal communication and progression in high-risk MB.