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Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy.

Ting ZhangXinrui YangWanping XuJing WangDawei WuZhixian HongShengxian YuanZhen ZengXiaodong JiaShanshan LuRifaat SafadiSen HanZhihong YangLeonard M NeckersSuthat LiangpunsakulWeiping ZhouYinying Lu
Published in: Cancer biology & medicine (2021)
HSP90 interacted with DDX5 protein and subsequently protected DDX5 protein from AMPK/ULK1-regulated autophagic degradation. DDX5 and HSP90 are therefore potential therapeutic targets for HCC.
Keyphrases
  • heat shock protein
  • heat shock
  • cell death
  • signaling pathway
  • protein protein
  • amino acid
  • oxidative stress
  • endoplasmic reticulum stress
  • transcription factor
  • binding protein
  • heat stress
  • small molecule
  • climate change