Neurofilament Light Chain Levels in Anti-NMDAR Encephalitis and Primary Psychiatric Psychosis.
Mar GuaspLorena Martín-AguilarLidia SabaterMiquel BioqueThaís ArmangueEugenia Martínez-HernándezJon LandaEstibaliz MaudesRoger BorràsAmaia Muñoz-LopetegiAlbert SaizJosefina Castro-FornielesFrancesc GrausEduard ParelladaLuis Antonio Querol-GutiérrezJosep O DalmauPublished in: Neurology (2022)
NfL measured at diagnosis of NMDARe associated with features of disease severity but not with long-term outcome. Young patients with FEP and sNfL ≥15 pg/mL had a 120 times higher chance of having NMDARe than those with pFEP. This cutoff correctly classified 96% of patients with pFEP and 85% of patients with NMDARe with isolated psychosis. Patients with FEP of unclear etiology and sNfL ≥15 pg/mL should undergo CSF NMDAR antibody testing.