Protective role of VEGF/VEGFR2 signaling against high fatality associated with hepatic encephalopathy via sustaining mitochondrial bioenergetics functions.

Ching-Yi TsaiJacqueline C C WuChiung-Ju WuSamuel H H Chan

Published in: Journal of biomedical science (2022)

Our results suggest that, acting via VEGFR2, the endogenous VEGF plays a protective role against high fatality associated with HE by amelioration of the dysregulated baroreflex-mediated sympathetic vasomotor tone through sustaining mitochondrial bioenergetics functions and eliciting antiapoptotic action in the RVLM.

Keyphrases

vascular endothelial growth factor
oxidative stress
endothelial cells
early onset