Genetic modifiers of cognitive decline in PSEN1 E280A Alzheimer's disease.

Diego Sepulveda-FallaJorge I VélezNatalia Acosta-BaenaAna BaenaSonia MorenoSusanne KrasemannFrancisco LoperaClaudio A MastronardiMauricio Arcos-Burgos

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

Impaired olfactory function has been associated with cognitive impairment in AD. Genetic variants in these or other genes could help to identify risk of faster memory decline in FAD and SAD patients.

Keyphrases

cognitive decline
mild cognitive impairment
cognitive impairment
end stage renal disease
ejection fraction
genome wide
newly diagnosed
chronic kidney disease
early onset
peritoneal dialysis
prognostic factors
working memory
gene expression
patient reported outcomes
copy number
bioinformatics analysis