Use of furosemide in preterm neonates with acute kidney injury is associated with increased mortality: results from the TINKER registry.

In preterm neonates with AKI, mortality was independently associated with furosemide treatment. The furosemide usage rates were higher in neonates with associated co-morbidities, i.e. significant cardiac diseases or surgical interventions. Sicker babies needed more resuscitation at birth, and died early, and hence needed shorter furosemide courses. Thus, survival probability was higher in neonates treated with long furosemide courses vs. short courses. A higher resolution version of the Graphical abstract is available as Supplementary information.