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Role of m 6 A modifications in immune evasion and immunotherapy.

Chunyu WuLvyuan LiQiling TangQianjin LiaoPan ChenCan GuoZhaoyang ZengZhaoyang Zeng
Published in: Medical oncology (Northwood, London, England) (2024)
RNA modification has garnered increasing attention in recent years due to its pivotal role in tumorigenesis and immune surveillance. N 6 -methyladenosine (m 6 A) modification is the most prevalent RNA modification, which can affect the expression of RNA by methylating adenylate at the sixth N position to regulate the occurrence and development of tumors. Dysregulation of m 6 A affects the activation of cancer-promoting pathways, destroys immune cell function, maintains immunosuppressive microenvironment, and promotes tumor cell growth. In this review, we delve into the latest insights into how abnormalities in m 6 A modification in both tumor and immune cells orchestrate immune evasion through the activation of signaling pathways. Furthermore, we explore how dysregulated m 6 A modification in tumor cells influences immune cells, thereby regulating tumor immune evasion via interactions within the tumor microenvironment (TME). Lastly, we highlight recent discoveries regarding specific inhibitors of m 6 A modulators and the encapsulation of m 6 A-targeting nanomaterials for cancer therapy, discussing their potential applications in immunotherapy.
Keyphrases
  • cancer therapy
  • stem cells
  • signaling pathway
  • public health
  • small molecule
  • squamous cell carcinoma
  • working memory
  • papillary thyroid
  • climate change