The prevalence and clinical context of antimicrobial resistance amongst medical inpatients at a referral hospital in Rwanda: a cohort study.
Olivier BizimunguPeter CrookJean Félix BabaneLéopold BitunguhariPublished in: Antimicrobial resistance and infection control (2024)
This cohort highlights high rates of resistance amongst Gram-negative organisms in Rwanda, including the presence of carbapenem resistance. Nonetheless, the detailed prescribing data also highlight the challenges of using routine laboratory data to infer broader AMR prevalence. The significant exposure to empiric broad-spectrum antibiotic therapy prior to culturing introduces a selection bias and risks over-estimating the burden of resistant organisms. Broadening access to microbiological services and active surveillance outside of teaching hospitals are essential to support national and international efforts to curb the growth of AMR in low-resource settings.
Keyphrases
- gram negative
- antimicrobial resistance
- multidrug resistant
- healthcare
- primary care
- risk factors
- electronic health record
- quality improvement
- big data
- acinetobacter baumannii
- drug resistant
- adverse drug
- clinical practice
- klebsiella pneumoniae
- stem cells
- machine learning
- urinary tract infection
- medical students
- bone marrow
- pseudomonas aeruginosa
- climate change
- risk assessment
- data analysis
- acute care
- health insurance