Structure, Dynamics, and Impact of Replication Stress-Induced Structural Variants in Hepatocellular Carcinoma.

Quentin BayardPierre CordierCamille Péneau Sandrine Imbeaud Theo Z HirschVictor RenaultJean-Charles NaultJean-Frédéric BlancJulien CalderaroChantal DesdouetsJessica Zucman-Rossi Eric Letouzé

Published in: Cancer research (2022)

Optical mapping and whole-genome sequencing integration unravels a unique signature of replication stress-induced structural variants that drive genomic evolution and the acquisition of driver events in CCN-HCC.

Keyphrases

stress induced
copy number
high resolution
genome wide
dna methylation
high speed
gene expression
high density