Hepatocyte differentiation from mouse liver ductal organoids by transducing 4 liver-specific transcription factors.

Katsuhiro Tomofuji Jumpei Kondo Kunishige OnumaRoberto CoppoHiroshi HorieKoki OyamaEiji Miyoshi Ken Fukumitsu Takamichi Ishii Etsuro Hatano Masahiro Inoue

Published in: Hepatology communications (2023)

Transduction of the 4 transcription factors (Hnf4a, Foxa1, Prox1, and Hlf) is a promising strategy to promote the differentiation of LDOs to obtain mature hepatocyte-like cells with better functionality.

Keyphrases

transcription factor
liver injury
dna binding
drug induced
nuclear factor
induced pluripotent stem cells