Palladium(II)-catalyzed enantioselective intermolecular oxidative diarylation of internal enamides.

The construction of vicinal stereogenic centers via the simultaneous formation of two C-C bonds across alkenes under oxidative conditions is a stubborn challenge. Herein, we report a Pd(II)-catalyzed highly enantioselective intermolecular oxidative 1,2-diarylation reaction of internal enamides with aryl boronic acids, enabling the expedient construction of two vicinal stereocenters with excellent diastereo-, and enantioselectivities.