Three-dimensional DNA nanostructures for dual-color microRNA imaging in living cells via hybridization chain reaction.

Meng-Mei LvZhan Wu Ru-Qin Yu Jian-Hui Jiang

Published in: Chemical communications (Cambridge, England) (2021)

A well-defined 3D DNA nanostructure with precise composition was developed by stoichimetric combination of a DNA tetrahedron and Y-shaped DNA, which allowed multiplexed, signal-amplified fluorescence imaging of miRNAs in living cells via hybridization chain reaction.

Keyphrases

living cells
single molecule
fluorescence imaging
fluorescent probe
circulating tumor
photodynamic therapy
nucleic acid
cell free
high resolution
single cell
mass spectrometry
label free