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An investigation of a self-assembled cell-extracellular complex and its potentials in improving wound healing.

Danyan YeYaowen SunLujun YangJing Su
Published in: Journal of applied biomaterials & functional materials (2023)
Our studies suggested that HuMSCs can be multi-cultivated through adding ascorbic stimulation and ECM containing collagen and hyaluronic acid were enriched around the cells which self-assembly formed a cell-ECM complex. Cell-ECM complex can improve growth factors secretion remarkably which means it may promote wound healing by paracrine.
Keyphrases
  • wound healing
  • single cell
  • hyaluronic acid
  • cell therapy
  • extracellular matrix
  • induced apoptosis
  • mesenchymal stem cells
  • cell death
  • cell proliferation
  • oxidative stress