The vitamin D receptor gene as a determinant of survival in pancreatic cancer patients: Genomic analysis and experimental validation.
Federico InnocentiKouros OwzarChen JiangAmy S EtheridgeRaluca GordânAlexander B SibleyFlora MulkeyDonna NiedzwieckiDylan GlubbNicole NeelMark S TalamontiDavid J BentremEric SeiserJen Jen YehKatherine Van LoonHoward McLeodMark J RatainHedy L KindlerAlan P VenookYusuke NakamuraMichiaki KuboGloria M PetersenWilliam R BamletRobert R McWilliamsPublished in: PloS one (2018)
Our findings propose VDR as a novel determinant of survival in advanced pancreatic cancer patients. Common functional variation in this gene might interact with endogenous vitamin D and gemcitabine treatment to determine improved patient survival. These results support evidence for a modulatory role of the vitamin D pathway for the survival of advanced pancreatic cancer patients.