Evidence for the induction of Th2 inflammation by group 2 innate lymphoid cells in response to prostaglandin D2 and cysteinyl leukotrienes in allergic rhinitis.
Ichiro TojimaKoji MatsumotoHirotaka KikuokaShiori HaraSayuri YamamotoShino ShimizuHideaki KouzakiTakeshi ShimizuPublished in: Allergy (2019)
PGD2 -CRTH2 and cysLTs-CysLT1 axes may activate tissue-resident ILC2s to produce Th2 cytokines, IL-5 and IL-13, leading to the development of allergic inflammation in AR.