Investigating the extremes of the continuum of paracrine functions in CD34-/CD31+ CACs across diverse populations.

Rian Q Landers-RamosRyan M SappEmily VandeWaterJennifer MackoShawn RobinsonYan WangEva R ChinEspen E SpangenburgSteven J PriorJames M Hagberg

Published in: American journal of physiology. Heart and circulatory physiology (2016)

S100A8 and S100A9 proteins in concentrations secreted by CD34-/CD31+ circulating angiogenic cells (CACs) with impaired function reduce endothelial cell capillary-like network formation. These effects appear to be mediated by Toll-like receptor 4 and are absent with S100A8 and S100A9 in concentrations secreted by healthy CD34-/CD31+ CACs.

Keyphrases

toll like receptor
nuclear factor
induced apoptosis
inflammatory response
endothelial cells
immune response
cell cycle arrest
endoplasmic reticulum stress
oxidative stress
cell death