Investigating the extremes of the continuum of paracrine functions in CD34-/CD31+ CACs across diverse populations.
Rian Q Landers-RamosRyan M SappEmily VandeWaterJennifer MackoShawn RobinsonYan WangEva R ChinEspen E SpangenburgSteven J PriorJames M HagbergPublished in: American journal of physiology. Heart and circulatory physiology (2016)
S100A8 and S100A9 proteins in concentrations secreted by CD34-/CD31+ circulating angiogenic cells (CACs) with impaired function reduce endothelial cell capillary-like network formation. These effects appear to be mediated by Toll-like receptor 4 and are absent with S100A8 and S100A9 in concentrations secreted by healthy CD34-/CD31+ CACs.