DNA repair in primordial follicle oocytes following cisplatin treatment.

Quynh-Nhu NguyenNadeen ZerafaJock K FindlayMartha HickeyKarla J Hutt

Published in: Journal of assisted reproduction and genetics (2021)

PMF oocytes are able to conduct high-fidelity repair of DNA damage accumulated during chemotherapy. Therefore, apoptosis inhibition presents a viable strategy for fertility preservation in women undergoing treatment.

Keyphrases

dna repair
dna damage
oxidative stress
endoplasmic reticulum stress
squamous cell carcinoma
cell death
pregnant women
signaling pathway
dna damage response
combination therapy
cell proliferation
locally advanced
skeletal muscle
childhood cancer
breast cancer risk